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Treatment with amoxicillin for 3 days for chest-indrawing pneumonia was non-inferior to treatment for 5 days in HIV-uninfected Malawian children
  1. Anna Athanasia Ntovolou1,
  2. Sarah Murphy2
  1. 1Department of Paediatrics, Barking Havering and Redbridge Hospitals NHS Trust, Romford, UK
  2. 2Department of Paediatrics, Mercy University Hospital, Cork, Ireland
  1. Correspondence to Dr Anna Athanasia Ntovolou, Department of Paediatrics, Barking Havering and Redbridge Hospitals NHS Trust, Romford RM7 0AG, UK; annaathanasia.ntovolou{at}nhs.net

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Review ofPerkin MR, Bahnson HT, Logan K, et al. Association of early introduction of solids with infant sleep. A secondary analysis of a randomized clinical trial. JAMA Pediatr 2018;172:e180739.

Study design: This is a prospective, double-blinded, randomised, placebo controlled, non-inferiority trial.

Allocation: Randomisation was used with 1:1 ratio according to age group and trial phase, in blocks of 2, 4 or 6.

Study question

Setting: The setting was two hospitals in a malaria-endemic area of Malawi.

Patients: Patients studied were 3000 HIV-uninfected children, aged 2–59 months, who presented to the outpatient departments of the two sites and met the WHO criteria for the case definition of chest-indrawing pneumonia. Exclusion criteria included severe anaemia, severe respiratory distress at presentation, antibiotics …

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Footnotes

  • Twitter @anna_ntovolou

  • Contributors AAN wrote the abstract; SM wrote the commentary; and both approved the final version.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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