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Review ofVan Kempen AAMW, Eskes PF, Nuytemans DHGM, et al. Lower versus traditional treatment thresholds for neonatal hypoglycaemia. N Engl J Med 2020;382:534–44
Allocation: 1:1 web-based block randomisation, stratified according to study centre and high-risk patient subgroup (preterm; small for gestational age; large for gestational ages; mothers with diabetes).
Design: The Hypoglycemia-Expectant Monitoring versus Intensive Treatment (HypoEXIT) trial was a multicentre, randomised, non-inferiority trial.
Setting: 17 academic or teaching hospitals in the Netherlands.
Patients: 689 otherwise healthy newborns born at 35 weeks gestation or later and identified as being at risk for hypoglycaemia.
Intervention: Treatment of blood glucose levels lower than 36 mg per decilitre (2.0 mmol/L).
Comparison: Treatment of blood glucose levels lower than 47 mg per decilitre (2.6 mmol/L).
Primary outcomes: Psychomotor development at 18 months, as measured by the Bayley Scales of Infant and Toddler Development. Bailey composite scores have a mean of 100, …
Contributors The abstract was written by KG. The commentary was written by RD and edited by AB.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; internally peer reviewed.
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