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Study design: An unblinded, multicentre, randomised non-inferiority trial.
Allocation: Computer-generated block randomisation sequence with random-sized blocks.
Setting: Nine Australian non-tertiary neonatal centres
Patients: 754 neonates <24 hours of age, ≥31 weeks of gestation, weighing ≥ 1200g who required non-invasive ventilatory support.
Intervention: Patients were randomised to receive either high-flow (HF) therapy or continuous positive airway pressure (CPAP) . Exclusion criteria included pre-randomisation CPAP for ≥ 2 hours, previous endotracheal intubation, a major congenital abnormality or clinician discretion.
Primary outcome: Treatment failure within 72 hours defined as either an oxygen requirement of ≥40%, pH of less than 7.2 with pCO2 …
Contributors The abstract was written by SW. The commentary was written by both SW and JOS. Both authors reviewed the final article.
Provenance and peer review Not commissioned; externally peer reviewed.
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