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Extended initial course of prednisolone did not improve clinical outcomes in steroid-sensitive nephrotic syndrome
  1. David Wands1,
  2. Ben C Reynolds2
  1. 1Gastroenterology, Hepatology and Clinical Nutrition, Royal Hospital for Children, Glasgow, UK
  2. 2Paediatric Renal Unit, Royal Hospital for Children, Glasgow, UK
  1. Correspondence to Dr David Wands, Gastroenterology, Hepatology and Clinical Nutrition, Royal Hospital for Children Glasgow, Glasgow G51 4TF, UK; david.wands{at}nhs.net

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Study design: Double-blind, parallel-group, randomised, placebo-controlled trial.

Setting and patients: 237 patients with steroid-sensitive idiopathic nephrotic syndrome aged 1–14 years recruited from 125 UK tertiary nephrology centres and district general hospitals.1

Intervention: Randomisation to standard 8-week course of prednisolone (60 mg/m2 for 4 weeks, then 40 mg/m2 alternate days for 4 weeks, total dose 2240 mg/m2) or an extended 16-week course (60 mg/m2 for 4 weeks, then 10 mg/m2 wean weekly for 12 weeks, total dose 3150 mg/m2).

Primary outcome: Time to first relapse.

Secondary outcomes: Relapse rate, use of alternative immunosuppression, …

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