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Study design: Double-blind, parallel-group, randomised, placebo-controlled trial.
Setting and patients: 237 patients with steroid-sensitive idiopathic nephrotic syndrome aged 1–14 years recruited from 125 UK tertiary nephrology centres and district general hospitals.1
Intervention: Randomisation to standard 8-week course of prednisolone (60 mg/m2 for 4 weeks, then 40 mg/m2 alternate days for 4 weeks, total dose 2240 mg/m2) or an extended 16-week course (60 mg/m2 for 4 weeks, then 10 mg/m2 wean weekly for 12 weeks, total dose 3150 mg/m2).
Primary outcome: Time to first relapse.
Secondary outcomes: Relapse rate, use of alternative immunosuppression, …
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