Statistics from Altmetric.com
- central hypothyroidism
- congenital hypopituitarism
- pituitary hormone deficiencies
- abnormal thyroid function
Four patients of term gestation were under review following the identification of abnormal thyroid function test (TFT). Patient 1 presented at 2 months of age with prolonged jaundice and cholestatic liver disease. Patient 2 presented at 1 month of age with prolonged jaundice and transaminitis. Both babies were active, thriving and did not have any feeding problems. Patient 3 had respiratory distress with hypotonia at birth and was treated for presumed Group B Streptococcus sepsis during the first week of life. He had soft dysmorphic features of hypertelorism, low set ears and retrognathia, poor suck and oropharyngeal dysphagia. He developed prolonged jaundice with transaminitis at 1 month of age and was developmentally delayed. Patient 4 presented at 19 months of age with faltering growth. Table 1 shows their cord blood thyroid stimulating hormone (TSH) screening and thyroid function trends following their presentation.
What is the most likely diagnosis in these patients?
Primary hypothyroidism with delayed TSH rise.
Euthyroid sick syndrome.
Thyroid binding globulin deficiency.
How would you manage them during follow-up? (choosing more than one option is …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.