Article Text

Childhood kidney disease is associated with increased risk of end-stage renal failure in adulthood
  1. Amanda Louise Newnham1,
  2. Amanda Jane Friend2,3
  1. 1Paediatric Nephrology, Leeds General Infirmary, Leeds, UK
  2. 2Paediatrics, Leeds General Infirmary, Leeds, UK
  3. 3School of Medicine, University of Leeds, Leeds, UK
  1. Correspondence to Dr Amanda Jane Friend, Paediatrics, Leeds General Infirmary, Leeds LS1 3EX, UK; amanda.friend{at}

Statistics from

Study question

Setting: Israel.

Patients: 1.5 million young people (aged 16–25) examined prior to military service between 1967 and 1997.

Exposure: Any history of childhood kidney disease, including structural anomalies and pyelonephritis.

Outcomes: Development of end-stage renal failure in adulthood.

Patient follow-up: Inclusion on the Israeli end-stage renal failure disease registry.

The study results are summarised in table 1.

View this table:
Table 1

Risks of adult end-stage renal disease based on history of childhood renal disease


A history of childhood renal disease, even if there is no evidence of renal impairment in adolescence, is associated with significantly increased risk of end-stage renal failure in adulthood.

Abstracted from: Calderon-Margalit R, …

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