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Cooling for longer or to lower temperatures has no effect on morbidity and mortality of neonates with hypoxic-ischaemic encephalopathy
  1. Kirsty E Elliott1,
  2. Peter Schulga2
  1. 1Paediatric Department, University Hospital Crosshouse, NHS Ayrshire and Arran, Ayr, UK
  2. 2Fraser of Allander Neurosciences Unit, Royal Hospital for Sick Children, Glasgow, UK
  1. Correspondence to Dr Kirsty E Elliott, NHS Ayrshire and Arran, Ayr KA7 1QJ, UK; kirsty.elliott2{at}nhs.net

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Study question: Neonates born at >36 weeks’ gestation with moderate to severe hypoxic-ischaemic encephalopathy (HIE) at 18 centres in the USA were enrolled.

Intervention: Neonates were randomised into four groups: 33.5°C for 72 hours (current practice); 32.0°C for 72 hours; 33.5°C for 120 hours; and 32.0°C for 120 hours.

Primary outcome: Death or moderate-severe disability rates at 18–22 months of age.

Secondary outcomes: Mortality rates postdischarge; disability level associated with stage of encephalopathy; cognitive score (Bayley Scale of Infant Development III) and motor score (Gross Motor Function Classification System); rates of visual, hearing and multiple disabilities; cerebral palsy rates; and rates of rehospitalisation and growth measurements.

Main results

364 neonates were enrolled …

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