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Propranolol reduced volume, colour and elevation of infantile haemangiomas

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Study design


Randomised controlled trial.


Randomised by clinical pharmacist using minimisation.


Staff members, caregivers and participants were blinded to group status.

Study question


Tertiary hospital in Australia.


Forty children between 9 weeks and 5 years of age, with infantile haemangiomas (IHs) that could impair function or were in sites with the potential for disfigurement, were too late for corticosteroid therapy (authors do not state a specific age), or had failed corticosteroid therapy.


Infants were randomised to oral propranolol 2 mg/kg/day or placebo.


Blinded evaluation of change in IHs volume, colour and elevation.

Follow-up period

Outcomes were assessed at 0, 4, 8, 12, 16, 20 and 24 weeks.

Patient follow-up

An intention to treat analysis was performed. At 2 …

Correspondence to Nick Brown, Salisbury District Hospital, Wilts, UK; n_janbrown{at}

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  • Sources of funding Sydney Children's Hospital Foundation, Pediatric Cardiac Fund, and the Touch by Olivia Foundation.


  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.

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