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Maternal first-trimester iodine deficiency predicts poor cognitive outcome in English children

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Study design

A geographically defined cohort of pregnant women, and the children resulting from those pregnancies.


A cohort of parents and children from ALSPAC (the Avon Longitudinal Study of Parents and Children). All pregnant women in the former Avon region of Southwest England were eligible for inclusion if they were expected to deliver between 1 April 1991 and 31 December 1992. 14 541 women were enrolled into ALSPAC as a whole but this study was limited by availability of a stored first-trimester urine sample in a singleton pregnancy and availability of IQ data of offspring at 8 years.


10440 mother–child pairs from the ALSPAC cohort were selected as described. The exposure was defined by previously WHO-validated criteria. The urinary iodine to creatinine ratio was dichotomised into deficient (<150 mcg/g) or replete (>150 mcg/g). Developmental …

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  • Provenance and peer review Not commissioned; internally peer reviewed.