You are here

Article Text

Article menu
Download PDFPDF
Picket
Hypothermia did not improve mortality or disability in severe traumatic brain injury

https://doi.org/10.1136/archdischild-2013-305596

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Study design

    Design: Randomised controlled trial (RCT).

    Allocation: Concealed web based algorithm to stratified by study site and age.

    Blinding: Treating doctors not masked—investigators assessing outcome were masked.

    Study question

    Setting: Multinational, multicentre paediatric intensive care unit—75% patients from three paediatric intensive care units (Davis, California; Dallas, Texas; Pittsburgh, Pennsylvania) in USA.

    Patients: Age 0–17 years non-penetrating brain injury; Glasgow coma scale (GCS) score 3–8 (motor score <6), available for randomisation within 6 h of injury. Excluded if any of: normal CT head, Glasgow coma scale score 3, unreactive pupils, hypotension, uncorrectable coagulopathy, hypoxia, multiple trauma, suspected pregnancy.

    Intervention: Thirty-nine patients were randomised to hypothermia (T32–33°C) for 48 h followed by slow rewarming and 38 patients were randomised to …

    View Full Text