Statistics from Altmetric.com
As paediatricians we are all very familiar with the concept of inheriting genes from generation to generation via DNA commonly referred to as ‘genetics’. In contrast the term ‘epigenetics’ at present remains rather ill defined for many. This brief article aims to introduce the concept of epigenetics and explain the meaning and main mechanisms involved. Moreover, it intends to give a glimpse of the exciting future perspectives for research into epigenetic and its relevance to paediatrics.
The word ‘epigenetics’ is a combination of the prefix ‘epi-,’ (Greek: ɛπί- over, above, outer) and genetics. It was first introduced in 1942 by the British developmental biologist Conrad Waddington who coined the term epigenetics as ‘the branch of biology which studies the causal interactions between genes and their products which bring the phenotype into being’.1 The idea behind this concept was to summarise all biological processes that connect the genotype of a single cell or a multicellular organism with the phenotype. Today we all know that our genotype is coded by DNA, the double helix that provides a ‘blueprint’ for everything that is produced in eukaryotic cells including human cells. However, while …
Competing interests None.
Provenance and peer review Commissioned; internally peer reviewed.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.