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Design: Randomised controlled trial.
Allocation: Randomisation was done by university staff. Allocation was concealed using sealed envelopes that were sequentially numbered.
Blinding: All patients, care providers and investigators were blinded. Only hyperbaric oxygen (HBO) technicians were aware of group assignment.
Setting: Ambulatory HBO clinic in the USA.
Patients: Forty-nine children aged 3 to 8 years with spastic cerebral palsy (CP), with no previous HBO treatments, recent thoracic surgery, changes of spasticity medications or history of hypoxic-ischaemic encephalopathy.
Intervention: Children were randomised to receive either hyperbaric 100% oxygen (HBO) or hyperbaric air (HBA), at 1.5 atmospheres, for 60 min, once per weekday for a total of 40 treatments.
Outcomes: Primary outcome was a change in Gross Motor Function Measure (GMFM-88) score. A change …
Correspondence to Dr Pérez-Gaxiola, Hospital Pediátrico de Sinaloa–Evidence-based medicine, Blvd Constitución y Donato Guerra SN Col. Almada, Culiacan 80200, Mexico
Correction notice This paper has been amended since it was published Online First. The correspondence address was incorrect and this has now been amended.