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Study design
Design
Randomised controlled trial.
Allocation
Computer generated allocation by independent statistician.
Blinding
Staff members were blind to the group of allocation at the time of outcome assessment. Parents were blinded to assigned formula until the child's second birthday.
Study question
Setting
Maternity hospital in Australia.
Patients
Six hundred and twenty infants with a history of allergy in a first degree relative (eczema, asthma, rhinitis, food allergy).
Intervention
Infants were randomised to three groups to receive at weaning: a partially hydrolysed whey formula (pHWF), conventional cow's milk formula (CMF) or a soy-based formula.
Outcomes
Primary outcome was any allergic manifestation (eczema or food reaction) assessed during telephone interviews. Secondary outcomes were individual incidence of allergies, and skin prick tests (SPTs) reactivity.
Follow-up period
Outcomes were assessed at to 2 years of life. Additionally, the 2-year period prevalence …
Correspondence to Paul L P Brand, Princess Amalia Children's Clinic, Isala klinieken Zwolle, the Netherlands p.l.p.brand{at}isala.nl
Footnotes
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Sources of funding Nestec, a subsidiary of Nestle Australia, provided the study formula and staff funding for the first 6 years of the study.
Footnotes
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Competing interests None.
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Provenance and peer review Commissioned; internally peer reviewed.