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Randomised controlled trial.
Randomised by clinical pharmacist using minimisation.
Staff members, caregivers and participants were blinded to group status.
Tertiary hospital in Australia.
Forty children between 9 weeks and 5 years of age, with infantile haemangiomas (IHs) that could impair function or were in sites with the potential for disfigurement, were too late for corticosteroid therapy (authors do not state a specific age), or had failed corticosteroid therapy.
Infants were randomised to oral propranolol 2 mg/kg/day or placebo.
Blinded evaluation of change in IHs volume, colour and elevation.
Outcomes were assessed at 0, 4, 8, 12, 16, 20 and 24 weeks.
An intention to treat analysis was performed. At 2 years, …
Correspondence to Nick Brown, Salisbury District Hospital, Wilts, UK;
Sources of funding Sydney Children's Hospital Foundation, Pediatric Cardiac Fund, and the Touch by Olivia Foundation.
Competing interests None.
Provenance and peer review Commissioned; internally peer reviewed.
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