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Review: most interventions for preventing bone disease in chronic renal failure improved biochemical outcomes

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In children with chronic renal failure at risk of bone disease, which interventions prevent or treat the condition?

Review scope

Studies were selected which compared any active intervention with any other or placebo in the treatment of children with renal failure to prevent bone disease.

Review methods

Cochrane Renal Group's specialised register, CCTR, MEDLINE, EMBASE, reference lists and abstracts were searched without language restriction. The quality of the studies was assessed by the Cochrane ‘risk of bias’ criteria. Fifteen studies were included.

Main results

The 15 studies included 369 patients, and undertook five different comparisons. Two of these (ergosterols and phosphate binders) are no longer used in clinical practice. The quality of the included studies varied, with most items showing low risk of bias in only one third of the included trials. …

Correspondence to Eric Finlay, Department of Paediatric Nephrology, Leeds General Infirmary, Leeds, UK; eric.finlay{at}

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  • Source(s) of funding None.


  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.