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  • In infants with ‘colic’/persistent crying, administration of daily Lactobacillus reuteri DSM 17938 was associated with reduced crying time at 1, 2 and 3 weeks

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In infants with ‘colic’/persistent crying, administration of daily Lactobacillus reuteri DSM 17938 was associated with reduced crying time at 1, 2 and 3 weeks

https://doi.org/10.1136/archdischild-2011-300204

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    Design: Single centre randomised controlled trial.

    Allocation: Computer generated random-digit randomisation.

    Blinding: Participants, physicians and statisticians.

    Setting: Tertiary hospital paediatric outpatient department, Turin, Italy, March 2008 to August 2009.

    Patients: Breast-fed infants (n=46) aged 2–16 weeks with persistent crying fulfilling Wessel's criteria for colic: crying for more than 3 h/day for more than 3 days/week for more than 3 weeks.

    Intervention: A 5 ml oil suspension of Lactobacillus reuteri or an identically appearing and tasting placebo oil.

    Outcomes: Primary: Reduction in mean daily crying time at day 21 of treatment to less than 3 h/day. Secondary: Reduction in daily mean crying time to less than 50% of baseline at 7, 14 and 21 days.

    Follow-up period: 21 days.

    Main results

    By day 21 median crying times were …

    Correspondence to Dr Nick Brown, Paediatric Department, Salisbury District Hospital, Salisbury SP2 8BJ, UK; n_janbrown{at}yahoo.co.uk

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    Footnotes

    • Sources of funding BioGaia AB Stockholm, Sweden

    Footnotes

    • Competing interests None.

    • Provenance and peer review Commissioned; internally peer reviewed.