I was interested in the excellent article on ‘How to use: C-reactive protein’ in Education & Practice by McWilliam and Riordan.1 I was particularly interested in the section on ‘ “Ruling in” sepsis’ and the comment that a raised C-reactive protein (CRP) is not diagnostic for sepsis in the neonate because it may be raised for other reasons. The article quotes prolonged rupture of membranes, and maternal fever both of which can be caused by local sepsis which may lead to infection in the neonate. An …