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Review: sweet solutions before immunisations reduced crying in infants

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In infants (patients), does giving sweet solutions before immunisations [intervention] reduce crying and pain (outcome)?

Review scope

Trials were selected that compared sucrose or glucose solutions given orally before immunisations in infants beyond the neonatal period to 12 months of age. Outcomes included crying, pain and surrogates such as heart rate and salivary cortisol.

Review methods

Medline, Embase, CINAHL, PsycINFO, EBM Reviews, reference lists, personal files and conference proceedings were searched for randomised controlled trials (RCTs). No language restriction was applied. Quality of studies was assessed using a six-point scale that included randomisation generation, allocation concealment, blinding and other sources of bias. Fourteen RCTs were included.

Main results

The 14 trials included a total …

Correspondence to Dr Giordano Pérez-Gaxiola, Evidence-based Medicine Department, Sinaloa's Pediatric Hospital, México; giordanoperez{at}

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  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.