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How to use C reactive protein: postscript
  1. Stephen McWilliam,
  2. Andrew Riordan
  1. Alder Hey Children's NHS Foundation Trust, Liverpool, UK
  1. Correspondence to Dr Andrew Riordan, Alder Hey Children's NHS Foundation Trust, Eaton Road, Liverpool L12 2AP, UK; andrew.riordan{at}

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We were grateful to a number of people who contacted us about our article on how to use C reactive protein (CRP).1

Abelian from Wrexham Maelor Hospital drew our attention to data on plasma half-life, suggesting this was 19 hours in an adult2 rather than the previously quoted 4–7 hours.3 4

Emmerson asked if there were robust data in support of the range of non-infectious conditions quoted to cause a rise in CRP in the newborn period. Our article had quoted a review by Hengst.5 We therefore reviewed the papers referenced in this review. Chiesa et al6 showed that mean CRP concentration at birth was increased by a factor of 1.50 (95% CI 1.32 to 2.03) if the 5-minute Apgar score was <8 and by a factor of 1.32 (95% CI …

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  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.