Article Text

Download PDFPDF
Paracetamol/codeine probably had equivalent analgesia to ibuprofen in children with extremity injuries

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Study design


Randomised double-blinded controlled trial.


Concealed (sealed opaque envelopes).


Blinded (patient, parent, investigator and treating physician).

Study question


Large emergency department in the USA.


68 children and young people, 5–17 years of age (mean age 10.4 years), who presented to the emergency department with a limb injury not requiring immediate treatment and a pain score of at least 5/10. Exclusion criteria included recent use (<6 h) of analgesics, allergy to study medicines, recent use of central nervous system altering substances, non-English language speakers and inability to use the pain scoring tool.


34 children were assigned to a single dose of ibuprofen (10 mg/kg, maximum 400 mg), and 34 were assigned to paracetamol–codeine (1 …

View Full Text


  • Provenance and peer review Commissioned; internally peer reviewed.