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Study design
Design
Randomised double-blinded controlled trial.
Allocation
Concealed (sealed opaque envelopes).
Blinding
Blinded (patient, parent, investigator and treating physician).
Study question
Setting
Large emergency department in the USA.
Patients
68 children and young people, 5–17 years of age (mean age 10.4 years), who presented to the emergency department with a limb injury not requiring immediate treatment and a pain score of at least 5/10. Exclusion criteria included recent use (<6 h) of analgesics, allergy to study medicines, recent use of central nervous system altering substances, non-English language speakers and inability to use the pain scoring tool.
Intervention
34 children were assigned to a single dose of ibuprofen (10 mg/kg, maximum 400 mg), and 34 were assigned to paracetamol–codeine (1 …
Footnotes
Provenance and peer review Commissioned; internally peer reviewed.
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