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How to use: C-reactive protein
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  • Published on:
    Non infectious CRP elevation and correlation with gestational age
    • Nora Hofer, Division of Neonatology
    • Other Contributors:
      • Bernhard Resch

    Non infectious CRP elevation and correlation with gestational age

    Dear editor, We read with interest the discussion on the reliability of CRP as a sepsis marker in the newborn in the context of non infectious conditions following the interesting article on the use of CRP by McWilliam and Riordan (1). We have recently conducted an analysis on this topic including 690 newborns having CRP values done within the firs...

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    Conflict of Interest:
    None declared.
  • Published on:
    How to use CRP - authors reply
    • Andrew Riordan, Consultant in Paediatric Infectious Diseases and Immunology
    • Other Contributors:
      • Stephen McWilliam

    We were grateful to a number of people who contacted us about our article on How to use C - reactive protein [1].

    Dr Abelian of Wrexham Maelor Hospital drew out attention to data on plasma half-life suggesting this was 19 hours in an adult [2] rather than the previously quoted 4-7 hours [3,4].

    Dr Emmerson asked if there was robust data in support of the range of non infectious conditions quoted to cause...

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    Conflict of Interest:
    None declared.
  • Published on:
    CRP is a useful marker in preterm infants
    • David Burgner, Principal Research Fellow, Infection, Immunity & Environment
    • Other Contributors:
      • Rebecca Howman, Tobias Strunk, Karen Simmer

    Dear Editors

    Re: How to use: C-reactive protein. McWilliam, et al. 95:55-58

    McWilliam and Riordan recently reviewed the use and limitations of C- reactive protein (CRP) in clinical practice, particularly in the diagnosis of infection.(1) The authors imply the authors suggest preterm infants cannot mount a CRP response (CRP levels remain low) when compared to term infants and older children. In the cont...

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    Conflict of Interest:
    None declared.
  • Published on:
    CRP - a marker of systemic inflammation
    • Jonathan L Marks, Specialty Registrar, Rheumatology
    • Other Contributors:
      • Dr Richard G Hull

    Dear Editor we read with interest the recent article regarding how to use C- reactive protein (CRP). While the authors discuss the role of CRP as a non-specific indicator of serious bacterial infection (SBI) they do not acknowledge that CRP is a non-specific indicator of systemic inflammation, the causes of which are many and varied with acute infective processes being only one.

    It is important to consider alter...

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    Conflict of Interest:
    None declared.
  • Published on:
    CRP and the Newborn Infant

    I was interested in the excellent article on How to use C-Reactive Protein in Education and Practice by McWilliam and Riordan. I was particularly interested in your comments in the article on Ruling in Sepsis and the comment that CRP is not diagnostic for sepsis in the neonate because it may be raised for other reasons. The article quotes - prolonged rupture of membranes - (most frequently caused by local sepsis and is...

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    Conflict of Interest:
    None declared.