Article Text

Download PDFPDF
Milk-free diet for cerebral folate deficiency syndrome

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

A clinical syndrome of psychomotor retardation, spastic paraplegia, cerebellar ataxia and dyskinesia associated with low cerebrospinal fluid (CSF) concentrations of 5-methyltetrahydrofolate and normal folate concentrations in plasma and red blood cells was described by Ramaekers and colleagues in 2002 and given the name cerebral folate deficiency syndrome (CFDS). The onset of symptoms and signs is usually 4–6 months after birth and seizures and autistic features may develop. Treatment is with pharmacological doses of …

View Full Text