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Evidence-based medicine
Review: omalizumab reduces exacerbation and steroid use in chronic asthma

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    Walker S, Monteil M, Phelan K, et al. Anti-IgE for chronic asthma in adults and children. Cochrane Database Syst Rev 2006;(2):CD003559.



    Q In adults and children with chronic asthma, is omalizumab (a recombinant humanised monoclonal anti-IgE referred to as rhuMAb-E25, rhu-Mab, or Xolair) better than placebo for clinical outcomes?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Respirology ★★★★★★☆ Paediatrics ★★★★★★☆ Allergy & immunology ★★★★★☆☆

    METHODS

    Embedded ImageData sources:

    Cochrane Airways Group Asthma and Wheeze trials register (up to February 2006), reference lists of relevant studies and review articles, all pharmaceutical companies producing anti-IgE formulations, 2 websites (www.fda.gov and www.clinicalstudyresults.org), meeting abstracts, and experts in the field.

    Embedded ImageStudy selection and assessment:

    randomised and blinded controlled trials (RCTs) in any language that included adults and children with chronic asthma and compared anti-IgE at any dose or route with placebo. 14 RCTs (n  =  3143) met the selection criteria. Quality …

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    Footnotes

    • For correspondence: Dr S Walker Education for Health, Warwick, UK. S.walker{at}educationforhealth.org.uk

    • Source of funding: no external funding.