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Q Does reduction in exposure to house dust mite (HDM) allergens and modification of dietary fatty acids in the first 5 years of life reduce the risk of asthma at 5 years of age?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Allergy & immunology ★★★★★★☆ Paediatrics ★★★★★☆☆
METHODS
Design:
randomised, 2×2 factorial design, placebo controlled trial.
Allocation:
{concealed*}†.
Blinding:
blinded {participants [diet intervention only], outcome assessors, and laboratory staff}†.*
Follow up period:
5 years.
Setting:
{antenatal clinics of 6 hospitals in Sydney, Australia.}†
Participants:
616 pregnant women (mean age 29 y), whose unborn singleton child was at increased risk of developing asthma because of asthma or frequent wheezing in a first degree relative. Exclusion criteria included a cat in the home and a vegetarian diet. Infants born at <36 weeks’ gestation, with birth weight <2.5 kg or significant congenital malformation or neonatal disease were withdrawn.
Interventions:
active HDM intervention (n = 308), consisting of an allergen impermeable barrier on …
Footnotes
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↵* See glossary. http://ebm.bmjjournals.com/cgi/content/full/12/1/???
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↵†
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For correspondence: Dr G B Marks Woolcock Institute of Medical Research, Camperdown, New South Wales, Australia. g.marks{at}unsw.edu.au
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Sources of funding: National Health and Medical Research Council of Australia and New South Wales Department of Health.