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Review: tissue transglutaminase test is almost as accurate as endomysial antibody test for diagnosis of coeliac disease

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Q How do the endomysial antibody (EMA) and tissue transglutaminase (tTG) tests compare with small bowel biopsy for diagnosis of coeliac disease in adults and children?

Clinical impact ratings IM/Ambulatory care ★★★★★☆☆ Gastroenterology ★★★★★★☆ Paediatrics ★★★★★★☆


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PubMed, Medline, Ovid (September 2005), and reference lists.

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published, peer reviewed studies in English that evaluated both the EMA and tTG tests in the same untreated patients and controls (adults or children). Coeliac disease had to be confirmed by histology of small bowel biopsy, with the criteria for diagnosis provided (partial or more severe villous atrophy in most studies). Biopsy was not required in controls, but the study had to state how many were biopsy …

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  • Reproduced with permission from Evidence-Based Medicine 2007


  • For correspondence: Dr B Scott, Lincoln County Hospital, Lincoln, UK. Brian.scott{at}

  • Source of funding: no external funding.