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Evidence-based medicine
Review: tissue transglutaminase test is almost as accurate as endomysial antibody test for diagnosis of coeliac disease

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    Lewis NR, Scott BB. Systematic review: the use of serology to exclude or diagnose coeliac disease (a comparison of the endomysial and tissue transglutaminase antibody tests). Aliment Pharmacol Ther2006;24:47–54.
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    Q How do the endomysial antibody (EMA) and tissue transglutaminase (tTG) tests compare with small bowel biopsy for diagnosis of coeliac disease in adults and children?

    Clinical impact ratings IM/Ambulatory care ★★★★★☆☆ Gastroenterology ★★★★★★☆ Paediatrics ★★★★★★☆

    METHODS

    Embedded ImageData sources:

    PubMed, Medline, Ovid (September 2005), and reference lists.

    Embedded ImageStudy selection and assessment:

    published, peer reviewed studies in English that evaluated both the EMA and tTG tests in the same untreated patients and controls (adults or children). Coeliac disease had to be confirmed by histology of small bowel biopsy, with the criteria for diagnosis provided (partial or more severe villous atrophy in most studies). Biopsy was not required in controls, but the study had to state how many were biopsy …

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    Footnotes

    • Reproduced with permission from Evidence-Based Medicine 2007

    Footnotes

    • For correspondence: Dr B Scott, Lincoln County Hospital, Lincoln, UK. Brian.scott{at}ulh.nhs.uk

    • Source of funding: no external funding.