Article info

Role of the selective cyclo-oxygenase-2 (COX-2) inhibitors in children
  1. Correspondence to:
    MrSean Turner
    Clinical Services, Princess Margaret Hospital, Roberts Road, Perth, Western Australia 6008, Australia; sean.turner{at}
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Turner S, Ford V
Role of the selective cyclo-oxygenase-2 (COX-2) inhibitors in children

Publication history

  • First published September 22, 2004.
Online issue publication 
September 22, 2004
  • Worldwide withdrawal of Vioxx (rofecoxib; Merck)

    One of the selective COX-2 inhibitors mentioned in this article (Vioxx (Rofecoxib; Merck)) has been voluntarily withdrawn by the manufacturer because of an increased relative risk for cardiovascular events, such as heart attack and stroke based on new, three-year data from a prospective, randomized, placebo-controlled clinical trial, the APPROVe (Adenomatous Polyp Prevention on VIOXX) trial.

    A press release issued by Merck is available online at

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