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Contributors The manuscript was conceptualised and developed by MTN with validation and input from IS, DH and KC. The original draft of the manuscript was written by MTN. Contributions to reviewing and editing the manuscript were provided by KC, IS and DH.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Disclaimer This is independent research carried out at the National Institute for Health and Care Research (NIHR) Alder Hey Clinical Research Facility (CRF). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.