You are here

Article Text

Article menu
Download PDFPDF
Key publications in paediatrics: Picket
Higher or lower haemoglobin transfusion thresholds for preterm infants?
  1. Fadi Maghrabia,
  2. Catherine M Harrison
  1. Neonatology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
  1. Correspondence to Dr Fadi Maghrabia, Neonatology, Leeds Teaching Hospitals NHS Trust, Leeds, UK; fadi.maghrabia{at}nhs.net

https://doi.org/10.1136/archdischild-2021-322641

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Review of: Kirpalani H, Bell EF, Hintz SR, et al. Higher or lower hemoglobin transfusion thresholds for preterm infants. N Engl J Med 2020;383:2639–51. doi:10.1056/nejmoa2020248

    Study design

    Design: Open multicentre randomised clinical trial.

    Allocation: Central telephone randomisation, stratified according to trial centre and birth weight (<750 g or 750–1000 g). Infants were assigned in a 1:1 ratio.

    Blinding: Follow-up assessments were masked to the intervention.

    Study question: Does a higher haemoglobin threshold for red-cell transfusions reduce the risk of cognitive delay among extremely low-birth-weight infants with anaemia?

    Setting: 41 NICUs (19 centres) in a Neonatal Research Network in the USA.

    Patients: 1824 infants aged under 48 hours with a birth weight less than 1001 g and gestational age 22+0 to 28+6 weeks. Infants with cardiac conditions, family history of haemoglobinopathy, prior transfusions or significant …

    View Full Text

    Footnotes

    • Twitter @cath_harrison10

    • Contributors Both authors contributed equally to the manuscript.

    • Provenance and peer review Not commissioned; internally peer reviewed.