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Study design: Superiority randomised controlled trial.
Allocation: Cluster randomisation with face mask or laryngeal mask airway (LMA).
Setting: Single-site maternity hospital in Uganda.
Patients: Babies born in hospital requiring positive pressure ventilation with gestational age of 34 weeks and weight of greater than 2 kg. Exclusion criteria include stillbirths and infants with major malformations affecting airways or incompatible with life.
Intervention: Resuscitation by a midwife with face mask or LMA.
Outcomes: The primary outcomes were neonatal intensive care unit (NICU) admission with moderate to severe hypoxic ischaemic encephalopathy (HIE) on days 1–5 of hospitalisation and composite of neonatal death within 7 days. The secondary outcomes included the need for advanced resuscitation, very early neonatal death within 24 hours of life, early neonatal death within 7 days, any hospital admission during …
Review of article Pejovic, Nicolas J., et al. A randomised trial of laryngeal mask airway in neonatal resuscitation. NEJM 2020;383;2138-47.
Twitter @ayaz74382348, @oshea_jem
Contributors AA wrote the abstract and commentary. JEO edited the commentary.
Provenance and peer review Not commissioned; internally peer reviewed.