Article Text

Download PDFPDF
Perioral swelling in a previously well child
  1. Rowena Walker1,
  2. Kathryn Ferris1,
  3. Maura Scott1,
  4. Naomi McMahon2,
  5. Andras Szabo2,
  6. Alistair C Dick3,
  7. Sharon Christie4,
  8. Peter Mallett1
  1. 1 Paediatrics, Royal Belfast Hospital for Sick Children, Belfast, N.Ireland
  2. 2 Paediatric Gastroenterology, RBHSC, Belfast, N. Ireland
  3. 3 Paediatric Surgery, Royal Belfast Hospital for Sick Children, Belfast, Antrim, N.Ireland
  4. 4 Paediatric Infectious Diseases, Royal Belfast Hospital for Sick Children, Belfast, N.Ireland
  1. Correspondence to Dr Peter Mallett, Royal Belfast Hospital for Sick Children, Belfast BT12 6BA, Northern Ireland, UK; Peter.Mallett{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

A previously well 7-year-old girl presented with a 6-week gradual history of progressive lip swelling with oral mucosal discomfort (figure 1). There was no precipitating factor identified. She was systemically well. There was no history of mucosal ulceration, abdominal pain, diarrhoea, skin rashes, atopy or weight loss. She recently received oral antibiotics for the perioral swelling with little effect and was on no regular medication. There was no significant family history including autoinflammatory conditions nor exposure to tuberculosis.

Figure 1

Significant lip and perioral tissue swelling at presentation.

Examination revealed weight and height on second centiles. Perioral inspection revealed swelling of both lips and perioral tissues, angular cheilitis, lower lip fissures and erythema. Intraoral examination revealed oral mucosal and gingival inflammation. Systems examination, including perianal examination, was unremarkable.

Question 1

Which initial next step would be the single most appropriate in this case?

  1. Blood tests including full blood count, iron profile, micronutrient screen and stool for faecal calprotectin.

  2. Blood tests including serum IgE levels, compliment levels (C3/C4), and C1-esterase inhibitor (C1-INH) protein and function.

  3. Mucosal swab for viruses including herpes simplex virus (HSV), …

View Full Text


  • Twitter @SimEdRBHSC

  • Contributors PM developed the concept and coordinated. RW, KF, MS and PM were involved in manuscript design and draft reviews. NM, AS, ACD and SC were involved in patient management.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.