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Olanzapine was an effective additional antiemetic for children and young people undergoing highly emetogenic chemotherapy
  1. Amanda Jane Friend1,2,
  2. Bob Phillips3
  1. 1 Paediatrics, Leeds General Infirmary, Leeds, UK
  2. 2 School of Medicine, University of Leeds, Leeds, UK
  3. 3 Centre for Reviews and Dissemination, University of York Alcuin College, York, UK
  1. Correspondence to Dr Amanda Jane Friend, Paediatrics, Leeds General Infirmary, Leeds LS1 3EX, UK; amanda.friend{at}

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Review of: Perkin MR, Bahnson HT, Logan K, et al. Association of early introduction of solids with infant sleep. A secondary analysis of a randomized clinical trial. JAMA Pediatr 2018;172:e180739.

Setting: Tertiary hospital in New Delhi, India.

Patients: Children aged between 5 and 18 years, weighing over 15 kg, who were scheduled to receive their first cycle of highly emetogenic chemotherapy.

Intervention: Olanzapine (0.14 mg/kg orally, once daily, rounded to the nearest 2.5 mg, up to a maximum of 10 mg) during treatment and for 3 days afterwards, in addition to a standard antiemetic regimen (ondansetron, dexamethasone and aprepitant) compared with standard antiemetic alone.

Outcomes: Number of patients with complete response to antiemetics with no vomiting and no severe nausea requiring rescue medication, assessed by hospital investigators during inpatient chemotherapy and reported …

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  • Twitter @the_learnaholic, @drbobphillips

  • Contributors AJF wrote the article, incorporating feedback and suggestions from BP.

  • Provenance and peer review Not commissioned; internally peer reviewed.