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  • Treatment with amoxicillin for 3 days for chest-indrawing pneumonia was non-inferior to treatment for 5 days in HIV-uninfected Malawian children

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Key publications in paediatrics: Picket
Treatment with amoxicillin for 3 days for chest-indrawing pneumonia was non-inferior to treatment for 5 days in HIV-uninfected Malawian children
  1. Anna Athanasia Ntovolou1,
  2. Sarah Murphy2
  1. 1 Department of Paediatrics, Barking Havering and Redbridge Hospitals NHS Trust, Romford, UK
  2. 2 Department of Paediatrics, Mercy University Hospital, Cork, Ireland
  1. Correspondence to Dr Anna Athanasia Ntovolou, Department of Paediatrics, Barking Havering and Redbridge Hospitals NHS Trust, Romford RM7 0AG, UK; annaathanasia.ntovolou{at}nhs.net

https://doi.org/10.1136/archdischild-2020-320880

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    Review of: Perkin MR, Bahnson HT, Logan K, et al. Association of early introduction of solids with infant sleep. A secondary analysis of a randomized clinical trial. JAMA Pediatr 2018;172:e180739.

    Study design: This is a prospective, double-blinded, randomised, placebo controlled, non-inferiority trial.

    Allocation: Randomisation was used with 1:1 ratio according to age group and trial phase, in blocks of 2, 4 or 6.

    Study question

    Setting: The setting was two hospitals in a malaria-endemic area of Malawi.

    Patients: Patients studied were 3000 HIV-uninfected children, aged 2–59 months, who presented to the outpatient departments of the two sites and met the WHO criteria for the case definition of chest-indrawing pneumonia. Exclusion criteria included severe anaemia, severe respiratory distress at presentation, …

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    Footnotes

    • Twitter @anna_ntovolou

    • Contributors AAN wrote the abstract; SM wrote the commentary; and both approved the final version.

    • Provenance and peer review Not commissioned; internally peer reviewed.