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Liraglutide does not provide sustainable results for weight improvement in adolescents with obesity
  1. Clare Brady1,
  2. M Guftar Shaikh2
  1. 1 General Paediatrics, Royal Hospital for Children, Glasgow, UK
  2. 2 Endocrinology, Royal Hospital for Sick Children, Glasgow, Glasgow, UK
  1. Correspondence to Dr Clare Brady, General paediatrics, Royal Hospital for Children, Glasgow G51 4TF, UK; c.brady1{at}

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Review of: Kelly AS, Auerbach P, Barrientos-Perez M, et al. A randomised, controlled trial of liraglutide for adolescents with obesity. N Engl J Med 2020 May;382:2117–2128. DOI: 10.1056/nejmoa1916038.

Allocation: Central randomisation using a web-based response system. Randomisation was stratified according to pubertal status and glycaemic status.

Setting: 32 sites over five countries (Belgium, Mexico, Russia, Sweden and the USA).

Intervention: All participants received lifestyle therapy. 125 were assigned to liraglutide and 126 assigned to the placebo group, receiving a volume matched equivalent.

Patients: 251 participants, aged 12 to <18 years. All participants were obese (defined as body mass index (BMI) of 30 or more), stable body weight (self-reported change of less than 5 kg during the 90 days before screening) and poor response …

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  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.