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Study design: Follow-up study based on the previously published Vitamin D Antenatal Asthma Reduction Trial. This was a randomised, double-blinded, placebo-controlled trial.
Study question: To determine whether high-dose vitamin D supplementation, taken during pregnancy, reduces the incidence of asthma and recurrent wheeze in offspring at 6-year follow-up.
Setting: Three clinical sites—Boston Medical Centre, Washington University and Kaiser Permanente Southern California Region.
Participants: 806 pregnant women, aged 18–39 years, and their offspring.
Intervention: 4000 IU/day vitamin D or a placebo tablet. All women also received a daily multivitamin containing 400 IU of vitamin D.
Primary outcome: Incidence of asthma or recurrent wheeze, either …
Review of article Litonjua AA, Carey VJ, Laranjo N, et al. Sixyear follow-up of a trial of antenatal vitamin D for asthma reduction. N Engl J Med 2020;382:525–33.
Contributors AAT wrote the manuscript. NB edited the manuscript.
Provenance and peer review Not commissioned; internally peer reviewed.