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Gestational vitamin D supplementation does not reduce asthma incidence in children at 6-year follow-up
  1. Andrew A Tester,
  2. Natalie Bee
  1. Emergency Department, Royal Hospital for Children, Glasgow, Scotland, UK
  1. Correspondence to Dr Andrew A Tester, Emergency Department, Royal Hospital for Children Glasgow, Glasgow, UK; andrewtester3291{at}

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Study design: Follow-up study based on the previously published Vitamin D Antenatal Asthma Reduction Trial. This was a randomised, double-blinded, placebo-controlled trial.

Study question: To determine whether high-dose vitamin D supplementation, taken during pregnancy, reduces the incidence of asthma and recurrent wheeze in offspring at 6-year follow-up.

Setting: Three clinical sites—Boston Medical Centre, Washington University and Kaiser Permanente Southern California Region.

Participants: 806 pregnant women, aged 18–39 years, and their offspring.

Intervention: 4000 IU/day vitamin D or a placebo tablet. All women also received a daily multivitamin containing 400 IU of vitamin D.

Primary outcome: Incidence of asthma or recurrent wheeze, either …

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  • Review of article Litonjua AA, Carey VJ, Laranjo N, et al. Sixyear follow-up of a trial of antenatal vitamin D for asthma reduction. N Engl J Med 2020;382:525–33.

  • Contributors AAT wrote the manuscript. NB edited the manuscript.

  • Provenance and peer review Not commissioned; internally peer reviewed.