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A 5-day course of penicillin V may be an effective treatment for streptococcal pharyngitis
  1. Stacy Wightman
  1. Neonatal Unit, University Hospital Wishaw, NHS Lanarkshire, Lanarkshire, UK
  1. Correspondence to Dr Stacy Wightman, Neonatal Unit, NHS Lanarkshire, Bothwell G12 0XH, UK; stacy.wightman{at}

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Review of: Skoog Ståhlgren G, Tyrstrup M, Edlund C, et al. Penicillin V four times daily for five days versus three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci: randomised controlled, open label, non-inferiority study. BMJ 2019;367:l5337.

Study design

Open label, randomised controlled non-inferiority study. Allocation: central randomisation by computerised random number generator. Setting: 17 primary health centres in Sweden. Intervention: randomised to either Penicillin V 800mg four times per day for 5 days (total 16g) or Penicillin V 1000mg three times per day for 10 days. (total 30g). Patients: 422 patients, aged 6 years and older with pharyngotonsillitis caused by group A streptococci and with three …

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  • Contributors The abstract and commentary were written by Stacy Wightman.

  • Provenance and peer review Not commissioned; internally peer reviewed.