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High-dose vitamin D supplementation in pregnancy reduces rates of enamel defects in children
  1. Andrew A Tester1,
  2. Francesca Capaldi2
  1. 1 Emergency Department, Royal Hospital for Children Glasgow, Glasgow, UK
  2. 2 NHS Lothian, Dentist within the Paediatric Oral Health Service, Scotland, UK
  1. Correspondence to Dr Andrew A Tester, Emergency Department, Royal Hospital for Children Glasgow, Glasgow G51 4TF, UK; andrewtester3291{at}

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Review of: Nørrisgaard PE, Haubek D, Kühnisch J, et al. Association of high-dose vitamin D supplementation during pregnancy with the risk of enamel defects in offspring: A 6-year follow-up of a randomized clinical trial. JAMA Pediatr

Study design

Post hoc secondary analysis of the participants recruited to the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) study. The researchers and dental examiner were blinded to treatment allocation. Participants were randomised using computer-generated random numbers.

Study question

To determine the effects of high-dose vitamin D supplementation in pregnant women, on enamel defects in their offspring.

Setting: Conducted in Denmark, at the Gentofte and Naestved Hospitals. Participants: 623 women and 588 corresponding children were recruited, between …

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  • Contributors AAT wrote the abstract. FC wrote the commentary.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.