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Review of: Van Kempen AAMW, Eskes PF, Nuytemans DHGM, et al. Lower versus traditional treatment thresholds for neonatal hypoglycaemia. N Engl J Med 2020;382:534–44
Allocation: 1:1 web-based block randomisation, stratified according to study centre and high-risk patient subgroup (preterm; small for gestational age; large for gestational ages; mothers with diabetes).
Design: The Hypoglycemia-Expectant Monitoring versus Intensive Treatment (HypoEXIT) trial was a multicentre, randomised, non-inferiority trial.
Setting: 17 academic or teaching hospitals in the Netherlands.
Patients: 689 otherwise healthy newborns born at 35 weeks gestation or later and identified as being at risk for hypoglycaemia.
Intervention: Treatment of blood glucose levels lower than 36 mg per decilitre (2.0 mmol/L).
Comparison: Treatment of blood glucose levels lower than 47 mg per decilitre (2.6 mmol/L).
Primary outcomes: Psychomotor development at 18 months, as measured by the Bayley Scales of Infant and Toddler Development. Bailey composite scores have a mean of …
Contributors The abstract was written by KG. The commentary was written by RD and edited by AB.
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.