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Lower glucose treatment threshold could be as safe as the traditional threshold in hypoglycaemic neonates
  1. Kirsty Gray1,
  2. Rebecca Dalrymple2,
  3. Andrew Brunton3
  1. 1 Royal Hospital for Children, Glasgow, UK
  2. 2 Royal Alexandra Hospital, Paisley, Renfrewshire, UK
  3. 3 Neonatology, Royal Hospital for Children Glasgow, Glasgow, UK
  1. Correspondence to Dr Kirsty Gray, Royal Hospital for Children, Glasgow G51 4TF, UK; kirsty.gray5{at}

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Review of: Van Kempen AAMW, Eskes PF, Nuytemans DHGM, et al. Lower versus traditional treatment thresholds for neonatal hypoglycaemia. N Engl J Med 2020;382:534–44

Allocation: 1:1 web-based block randomisation, stratified according to study centre and high-risk patient subgroup (preterm; small for gestational age; large for gestational ages; mothers with diabetes).

Design: The Hypoglycemia-Expectant Monitoring versus Intensive Treatment (HypoEXIT) trial was a multicentre, randomised, non-inferiority trial.

Setting: 17 academic or teaching hospitals in the Netherlands.

Patients: 689 otherwise healthy newborns born at 35 weeks gestation or later and identified as being at risk for hypoglycaemia.

Intervention: Treatment of blood glucose levels lower than 36 mg per decilitre (2.0 mmol/L).

Comparison: Treatment of blood glucose levels lower than 47 mg per decilitre (2.6 mmol/L).

Primary outcomes: Psychomotor development at 18 months, as measured by the Bayley Scales of Infant and Toddler Development. Bailey composite scores have a mean of …

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  • Contributors The abstract was written by KG. The commentary was written by RD and edited by AB.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.