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Salbutamol administered preoperatively to children undergoing tonsillectomy resulted in a significant reduction in rates of respiratory adverse events
  1. Andrew A Tester1,
  2. Anne Devenny2,
  3. Rebecca Dalrymple3
  1. 1 Emergency Department, Royal Hospital for Children, Glasgow, Scotland, UK
  2. 2 Respiratory Medicine, Royal Hospital For Sick Children, Yorkhill, Greater Glasgow and Clyde NHS Trust, Glasgow, Scotland, UK
  3. 3 General Paediatrics, Royal Hospital for Children, Glasgow, Scotland, UK
  1. Correspondence to Dr Andrew A Tester, Emergency Department, Royal Hospital for Children Glasgow, Glasgow G51 4TF, UK; andrewtester3291{at}

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Review ofVon Ungern-Sternberg BS, Sommerfield D, Slevin L, Drake-Brockman TFE, Zhang G, Hall GL. Effect of albuterol premedication vs placebo on the occurrence of respiratory adverse events in children undergoing tonsillectomies: the REACT randomized clinical trial. JAMA Pediatr 2019

Study design: Randomised, placebo-controlled trial. Participants were randomly allocated to an intervention using computer-generated block randomisation. Initially stratified based on administration method, but due to a change in practice favouring laryngeal mask airways over endotracheal tubes, in all ages, this was ceased.

Study question: To ascertain whether preoperative inhaled salbutamol reduces the rates of perioperative respiratory events in children undergoing tonsillectomies under general anaesthesia.

Setting: Perth Children’s Hospital, Western Australia.

Participants: 484 children, aged 0–8 years, undergoing general anaesthesia for tonsillectomy (+/− other ENT procedures including adenoidectomy).

Intervention: Preoperative administration of salbutamol (200 µg), administered via a metered …

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  • Contributors AAT wrote and edited the abstract, and reviewed the final proof. AD wrote the commentary. RD wrote and edited the commentary.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; internally peer reviewed.