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Review ofVon Ungern-Sternberg BS, Sommerfield D, Slevin L, Drake-Brockman TFE, Zhang G, Hall GL. Effect of albuterol premedication vs placebo on the occurrence of respiratory adverse events in children undergoing tonsillectomies: the REACT randomized clinical trial. JAMA Pediatr 2019
Study design: Randomised, placebo-controlled trial. Participants were randomly allocated to an intervention using computer-generated block randomisation. Initially stratified based on administration method, but due to a change in practice favouring laryngeal mask airways over endotracheal tubes, in all ages, this was ceased.
Study question: To ascertain whether preoperative inhaled salbutamol reduces the rates of perioperative respiratory events in children undergoing tonsillectomies under general anaesthesia.
Setting: Perth Children’s Hospital, Western Australia.
Participants: 484 children, aged 0–8 years, undergoing general anaesthesia for tonsillectomy (+/− other ENT procedures including adenoidectomy).
Intervention: Preoperative administration of salbutamol (200 µg), administered via a metered …
Footnotes
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Contributors AAT wrote and edited the abstract, and reviewed the final proof. AD wrote the commentary. RD wrote and edited the commentary.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; internally peer reviewed.
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