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Contributors CE came up with the concept. All three authors drafted the manuscript and approved the final draft.
Funding CE is supported by the Wellcome Trust (203905/Z/16/Z). FCF is supported by the National Institute for Health Research and the National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London. AJC is supported by an MRC Clinician Scientist Fellowship.
Competing interests None declared.
Patient consent Not required.
Provenance and peer review Commissioned; externally peer reviewed.