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Double blind, randomised controlled trial.
Patients: 1871 adults and adolescents (mean age 57 years) who had a diagnosis of asthma, were being treated with inhaled corticosteroid (ICS) and had had at least one exacerbation requiring systemic glucocorticoid treatment in the preceding 12 months.
Intervention: Quadrupling dose of ICS at the early loss of asthma control (vs usual dose of ICS; both groups increased bronchodilator as required).
Outcomes: Rates of asthma exacerbation requiring treatment with systemic glucocorticoids or an unscheduled healthcare visit.
The study’s main results are summarised in table 1.
Temporary quadrupling of ICS dose at the early signs of loss of asthma control results in a lower rate of severe asthma …
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