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Study 1
Study design
Double blind, randomised controlled trial.
Study question
Setting: UK.
Patients: 1871 adults and adolescents (mean age 57 years) who had a diagnosis of asthma, were being treated with inhaled corticosteroid (ICS) and had had at least one exacerbation requiring systemic glucocorticoid treatment in the preceding 12 months.
Intervention: Quadrupling dose of ICS at the early loss of asthma control (vs usual dose of ICS; both groups increased bronchodilator as required).
Outcomes: Rates of asthma exacerbation requiring treatment with systemic glucocorticoids or an unscheduled healthcare visit.
Main results
The study’s main results are summarised in table 1.
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Summary of asthma exacerbations in patients treated with quadrupled dose of ICS vs usual-dose ICS during the 12-month trial period
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Conclusion
Temporary quadrupling of ICS dose at the early signs of loss of asthma control results in a lower rate of severe asthma …
Footnotes
Provenance and peer review Not commissioned; internally peer reviewed.