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Childhood kidney disease is associated with increased risk of end-stage renal failure in adulthood
  1. Amanda Louise Newnham1,
  2. Amanda Jane Friend2,3
  1. 1 Paediatric Nephrology, Leeds General Infirmary, Leeds, UK
  2. 2 Paediatrics, Leeds General Infirmary, Leeds, UK
  3. 3 School of Medicine, University of Leeds, Leeds, UK
  1. Correspondence to Dr Amanda Jane Friend, Paediatrics, Leeds General Infirmary, Leeds LS1 3EX, UK; amanda.friend{at}

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Study question

Setting: Israel.

Patients: 1.5 million young people (aged 16–25) examined prior to military service between 1967 and 1997.1

Exposure: Any history of childhood kidney disease, including structural anomalies and pyelonephritis.

Outcomes: Development of end-stage renal failure in adulthood.

Patient follow-up: Inclusion on the Israeli end-stage renal failure disease registry.

The study results are summarised in table 1.

View this table:
Table 1

Risks of adult end-stage renal disease based on history of childhood renal disease


A history of childhood renal disease, even if there is no evidence of renal impairment in adolescence, is associated with significantly increased risk of end-stage renal failure in adulthood.


1 Calderon-Margalit R, …

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  • Provenance and peer review Not commissioned; internally peer reviewed.