Low or absent immunoglobulin A (IgA) levels are frequently found in children in whom immunodeficiency is not suspected. IgA deficiency is the most common primary immunodeficiency disorder in the UK affecting approximately 1 in 600 people. Isolated IgA deficiency is often identified coincidentally when investigating a child for conditions such as coeliac disease. The aim of this article is to provide a structured approach to the history, investigation and management of an isolated IgA deficiency.
- immunoglobulin A deficiency
- selective IgA deficiency
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All authors contributed equally to this paper.
AS, RMB and RH contributed equally.
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.