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Cooling for longer or to lower temperatures has no effect on morbidity and mortality of neonates with hypoxic-ischaemic encephalopathy
  1. Kirsty E Elliott1,
  2. Peter Schulga2
  1. 1 Paediatric Department, University Hospital Crosshouse, NHS Ayrshire and Arran, Ayr, UK
  2. 2 Fraser of Allander Neurosciences Unit, Royal Hospital for Sick Children, Glasgow, UK
  1. Correspondence to Dr Kirsty E Elliott, NHS Ayrshire and Arran, Ayr KA7 1QJ, UK; kirsty.elliott2{at}

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Study question: Neonates born at >36 weeks’ gestation with moderate to severe hypoxic-ischaemic encephalopathy (HIE) at 18 centres in the USA were enrolled.

Intervention: Neonates were randomised into four groups: 33.5°C for 72 hours (current practice); 32.0°C for 72 hours; 33.5°C for 120 hours; and 32.0°C for 120 hours.

Primary outcome: Death or moderate-severe disability rates at 18–22 months of age.

Secondary outcomes: Mortality rates postdischarge; disability level associated with stage of encephalopathy; cognitive score (Bayley Scale of Infant Development III) and motor score (Gross Motor Function Classification System); rates of visual, hearing and multiple disabilities; cerebral palsy rates; and rates of rehospitalisation and growth measurements.

Main results

364 neonates were enrolled …

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  • Contributors The abstract was written by KEE, with guidance from Dr R Dalrymple, while the commentary was written by PS.

  • Provenance and peer review Not commissioned; internally peer reviewed.