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Study question: Neonates born at >36 weeks’ gestation with moderate to severe hypoxic-ischaemic encephalopathy (HIE) at 18 centres in the USA were enrolled.
Intervention: Neonates were randomised into four groups: 33.5°C for 72 hours (current practice); 32.0°C for 72 hours; 33.5°C for 120 hours; and 32.0°C for 120 hours.
Primary outcome: Death or moderate-severe disability rates at 18–22 months of age.
Secondary outcomes: Mortality rates postdischarge; disability level associated with stage of encephalopathy; cognitive score (Bayley Scale of Infant Development III) and motor score (Gross Motor Function Classification System); rates of visual, hearing and multiple disabilities; cerebral palsy rates; and rates of rehospitalisation and growth measurements.
364 neonates were enrolled …
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