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Initial use of high-flow oxygen did not reduce duration of oxygen therapy in infants with bronchiolitis
  1. Amanda J Friend1,2
  1. 1 Department of Paediatrics, Leeds General Infirmary, Leeds, UK
  2. 2 School of Medicine, University of Leeds, Leeds, UK
  1. Correspondence to Dr Amanda J Friend, Department of Paediatrics, Leeds General Infirmary, University of Leeds School of Medicine, Leeds, LS1 3EX, UK; amanda.friend{at}

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Study design

Design: Randomised controlled trial.

Allocation: Randomised manually with stratification for gestational age.

Blinding: Unblinded.

Study question

Setting: A tertiary paediatric centre in New South Wales, Australia.

Patients: Infants presenting to the emergency department or paediatric ward with a diagnosis of moderately severe bronchiolitis who required oxygen therapy.

Intervention: Initial treatment with standard low flow or high flow (1 L/kg/min up to a maximum of 20 L/min), warm humidified oxygen.

Outcomes: Primary outcome was time to weaning off oxygen. Secondary outcomes were 24 hours event-free survival (ie, without treatment failure), proportion of serious events, transfer to ICU, length of stay and acceptability of treatment.

Follow-up period: 30 days post discharge.

Main results

The results …

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  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.