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Subcutaneous calcifications and hypothyroidism: Is there a missing link?
  1. Dinesh Giri1,
  2. Ravi Jayaram2,
  3. Senthil Senniappan1
  1. 1 Department of Paediatric Endocrinology, Alder Hey Children's Hospital, Liverpool, UK
  2. 2 Department of Paediatrics, Countess of Chester NHS Foundation Trust, Chester, UK
  1. Correspondence to Dr Senthil Senniappan, Alder Hey Children's NHS Foundation Trust & University of Liverpool, Eaton Road, Liverpool L12 2AP, UK; brinjikji.waleed{at}

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A 5-year-old boy was referred with a history of multiple subcutaneous nodules since infancy. He was born at 42 weeks gestation with a birth weight of 3.2 kg. At 8 months of age, he was noted to have an excessive weight gain by the health visitor and was subsequently diagnosed with primary hypothyroidism and commenced on levothyroxine 50 μg once daily. He had a normal newborn congenital hypothyroidism screen. The thyroid autoimmune antibodies were normal.

By the age of 5 years, he had delayed walking, speech and learning difficulties. Mother gave a history of surgically removed calcified lesions on her back. His weight and height at presentation were 35.5 kg (+3.8 SDS) and 121.4 cm (1.6 SDS), respectively. On examination, he had multiple subcutaneous nodules over and behind the left knee, left forearm, right ankle, chest and abdomen (figures 1 and 2). Investigations revealed a …

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  • Contributors DG: drafted the initial manuscript and approved the final version. SS: revised the draft manuscript and approved the final version. RJ: involved in the clinical management and approved the final version.

  • Competing interests None declared.

  • Patient Consent Parental/guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.