Article Text

Download PDFPDF
Use of high or low FiO2 during initial resuscitation did not impact survival or neurodevelopmental outcomes of preterm infants
  1. Amanda Jane Friend1,2,
  2. Sam J Oddie3
  1. 1 Department of Paediatrics, Leeds General Infirmary, Leeds, UK
  2. 2 University of Leeds School of Medicine, Leeds, UK
  3. 3 Bradford Neonatology, Bradford Royal Infirmary, West Yorkshire, UK
  1. Correspondence to Dr Amanda Jane Friend, Paediatrics, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK; amanda.friend{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Study design

Design: Randomised controlled trial.

Allocation: Randomised using computer-generated list.

Blinding: Double-blind.

Study question

Setting: Three hospitals in Spain and the Netherlands.

Patients: Infants born before 32 weeks completed gestation.

Intervention: Initial resuscitation with low (0.3) or high (0.6/0.65) FiO2 immediately after delivery.

Outcomes: Prevalence of cerebral palsy and disability severity according to Bayley-III developmental scores at 24 months corrected age.

Follow-up period: Until 24 months corrected age.

Main results

Prevalence of mild, moderate and severe disability according to Bayley-III developmental scores at 24 months corrected age is summarised in Table 1.

View this table:
Table 1

Disability outcomes (pertcentages) for …

View Full Text


  • Contributors AJF wrote the structured abstract; SO wrote the commentary.

  • Provenance and peer review Not commissioned; internally peer reviewed.