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Critically ill children did not benefit from tight glycaemic control
  1. Angela Katrina Lucas-Herald1,
  2. Kenneth J Robertson2,
  3. Angela Katrina Lucas-Herald1
  1. 1 Developmental Endocrinology Research Group, University of Glasgow, Glasgow , UK
  2. 2 Royal Hospital for Children, Glasgow , UK
  1. Correspondence to Dr Angela Katrina Lucas-Herald, Developmental Endocrinology Research Group, University of Glasgow, 1345 Govan Road, Glasgow G51 4TF, UK; angela.lucas-herald{at}

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Study design

Design: Randomised controlled trial.

Allocation: Computer generated block design.

Study question

Setting: Thirty-five paediatric intensive care unit (ICU) centres.

Patients: Three hundred and sixty patients (median age 5.5 years, IQR 1.4–12.5 years) in the lower target group; 353 patients (median age 6.7 years, IQR 1.7–12.8 years) in the higher target group.

Intervention: Randomisation to low target glycaemic control group (80–110 mg/dL (4.4–6.1 mmol/L)) or higher target glycaemic control group (150–180 mg/dL (8.3–10 mmol/L).

Outcomes: Primary outcome: number of ICU-free days to day 28. Prespecified secondary outcomes: 90-day mortality, severity of organ dysfunction, the number of ventilator-free days to day 28, incidence of healthcare-associated infection and incidence of hypoglycaemia.

Patient follow-up: Patients were followed up for 90 days. Recruitment stopped at …

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  • Contributors AKL-H and KJR contributed equally to the preparation of the submitted manuscript.

  • Provenance and peer review Not commissioned; internally peer reviewed.