You are here

Article Text

Article menu
Download PDFPDF
Structured abstracts of sentinel articles: Picket
Metformin with insulin does not improve the glycaemic control of overweight/obese adolescents with type 1 diabetes
  1. Angela Katrina Lucas-Herald1,
  2. Kenneth J Robertson2
  1. 1 Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK
  2. 2 Royal Hospital for Children, Glasgow, UK
  1. Correspondence to Dr Angela Katrina Lucas-Herald, Developmental Endocrinology Research Group, University of Glasgow, 1345 Govan Road, Glasgow G51 4TF, UK; angela.lucas-herald{at}glasgow.ac.uk

http://dx.doi.org/10.1136/archdischild-2016-312326

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Study design

    Design: Placebo-controlled randomised controlled trial.

    Allocation: Via computer generated sequence.

    Blinding: Double-blind.

    Study question

    Setting: 26 paediatric endocrinology clinics in the Type 1 Diabetes Exchange Clinic Network between 2013 and 2014.

    Patients: 140 adolescents aged between 12.1 and 19.6 years (mean (SD) 15.3 (1.7)) with type 1 diabetes for >1 year and a body mass index >85th centile for age, total daily insulin dose >0.8 units/kg and three times daily self-monitoring of blood glucose.

    Intervention: 2000 mg daily dose metformin compared with placebo.

    Outcomes: Primary outcome: change in haemoglobin A1c (HbA1c) from baseline to 26 weeks. Prespecified secondary outcomes: total daily dose (TDD) insulin per kg body weight, total basal insulin per kg body weight, anthropometry, blood pressure, metabolic profile.

    Follow-up period …

    View Full Text

    Footnotes

    • Provenance and peer review Not commissioned; internally peer reviewed.