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Funding NJS is supported by an NIHR Senior Investigator award and OJA by an NIHR Clinician Scientist fellowship award (grant number NIHR-CS-012-002). NJS and JCH are partially funded by the Great Ormond Street Hospital Children's Charity and the NIHR Biomedical Research Centre at Great Ormond Street Hospital.
Disclaimer The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.
Competing interests None declared.
Ethics approval Local Research Ethics Committee.
Provenance and peer review Commissioned; externally peer reviewed.
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