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From the questions on page 185.
Answer to question 1
B—Langerhans cell histiocytosis (LCH): Abnormal clonal proliferation of histiocytes, resembling Langerhans cells, and its accumulation in different tissues and organs. LCH exhibits heterogeneous clinical pictures and evolution—it varies from the isolated cutaneous lesion with spontaneous resolution to severe cases involving the liver, spleen, lung and haematopoietic system.1 The most common skin lesion is similar to seborrhoeic dermatitis, but exhibits petechiae and purpura, and affects the scalp, eyebrows, ears and intertriginous areas.2 Seborrhoeic-like plaques resistant to conventional therapy, no improvement until 8 months of age (both facts described in case number 1), as well as the presence of hepatosplenomegaly should indicate the hypothesis of LCH and, therefore, skin biopsy …
Competing interests None.
Patient consent Obtained.
Ethics approval Comite de Ética do Hospital de Clinicas da UFPR.
Provenance and peer review Not commissioned; internally peer reviewed.
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